Flavonoids with antinociceptive and anti-inflammatory activities from the leaves of Tilia argentea (silver linden)

J Ethnopharmacol. 2004 Dec;95(2-3):393-7. doi: 10.1016/j.jep.2004.08.008.


Silver linden, Tilia argentea Desf. ex DC (Tiliaceae) leaves are used in the treatment of common cold and bronchitis. In order to evaluate this information, antinociceptive and anti-inflammatory activities of the two main flavonoid glycosides: kaempferol-3,7-O-alpha-dirhamnoside and quercetin-3,7-O-alpha-dirhamnoside isolated from the leaves, were investigated. For the antinociceptive activity, p-benzoquinone-induced writhing test and for the anti-inflammatory activity, carrageenan-induced hind paw edema model in mice were used. Both compounds were shown to possess potent antinociceptive and anti-inflammatory activity at 50 mg/kg dose, per os, without inducing any apparent acute toxicity as well as gastric damage.

Publication types

  • Comparative Study

MeSH terms

  • Analgesics / isolation & purification
  • Analgesics / pharmacology
  • Analgesics / therapeutic use*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Edema / drug therapy
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology
  • Flavonoids / therapeutic use*
  • Male
  • Mice
  • Pain Measurement / drug effects
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Leaves
  • Tilia*


  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Flavonoids
  • Plant Extracts