Electrolyte Therapy for Refractory Seizures in Familial Dysautonomia

Epilepsia. 2004 Nov;45(11):1461-2. doi: 10.1111/j.0013-9580.2004.54403.x.

Abstract

Purpose: Video-EEG in a family of three patients with slow development and familial dysautonomia demonstrated absence seizures associated with 3-Hz generalized spike-and-wave discharges. The seizures were refractory to antiepileptic drugs (AEDs).

Methods: Treatment was given with rice-based cereal electrolyte oral solution.

Results: Treatment induced seizure freedom and normalization of EEG in all three patients. Repeated video-EEG monitoring with discontinuation of AEDs and maintenance of the oral hydration therapy was associated with recurrence of epileptic activity. All three patients have remained seizure free (approximately 1 year) with a combination of topiramate and electrolytic therapy.

Conclusions: Rice-based oral electrolyte hydration therapy may play a role in prevention and control of seizures in patients with familial dysautonomia.

Publication types

  • Letter

MeSH terms

  • Anticonvulsants / therapeutic use
  • Carbohydrates / administration & dosage
  • Citrates / administration & dosage
  • Comorbidity
  • Dysautonomia, Familial / epidemiology
  • Dysautonomia, Familial / therapy*
  • Electrolytes / administration & dosage
  • Electrolytes / therapeutic use*
  • Epilepsy / drug therapy
  • Epilepsy / epidemiology
  • Epilepsy / therapy*
  • Humans
  • Oryza
  • Potassium / administration & dosage
  • Rehydration Solutions / administration & dosage*
  • Sodium / administration & dosage
  • Treatment Outcome

Substances

  • Anticonvulsants
  • Carbohydrates
  • Citrates
  • Electrolytes
  • Rehydration Solutions
  • Sodium
  • Potassium