An expansion of Simons' integrated hypothesis of trigger point formation

Curr Pain Headache Rep. 2004 Dec;8(6):468-75. doi: 10.1007/s11916-004-0069-x.

Abstract

Simons' integrated hypothesis proposed a model of trigger point (TrP) activation to explain known TrP phenomena, particularly endplate noise. We propose an expansion of this hypothesis to account for new experimental data and established muscle pathophysiology.

Publication types

  • Review

MeSH terms

  • Acetylcholine / metabolism
  • Acetylcholinesterase / physiology
  • Animals
  • Calcitonin Gene-Related Peptide / physiology
  • Humans
  • Hydrogen-Ion Concentration
  • Motor Endplate / physiology
  • Muscle Contraction / physiology
  • Muscle, Skeletal / injuries
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiopathology
  • Myofascial Pain Syndromes / metabolism
  • Myofascial Pain Syndromes / physiopathology*
  • Myofascial Pain Syndromes / therapy
  • Nociceptors / physiology
  • Receptors, Cholinergic / physiology

Substances

  • Receptors, Cholinergic
  • Acetylcholinesterase
  • Calcitonin Gene-Related Peptide
  • Acetylcholine