Post-translational Modification of p53 in Tumorigenesis

Nat Rev Cancer. 2004 Oct;4(10):793-805. doi: 10.1038/nrc1455.

Abstract

Interest in the tumour suppressor p53 has generated much information regarding the complexity of its function and regulation in carcinogenesis. However, gaps still exist in our knowledge regarding the role of p53 post-translational modifications in carcinogenesis and cancer prevention. A thorough understanding of p53 will be extremely useful in the development of new strategies for treating and preventing cancer, including restoration of p53 function and selective killing of tumours with mutant TP53.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetylation
  • Acetyltransferases / physiology
  • Anticarcinogenic Agents / pharmacology
  • Carcinogens / pharmacology
  • Cell Transformation, Neoplastic / genetics*
  • DNA / metabolism
  • Genes, p53*
  • Humans
  • Mutation
  • Neoplasm Proteins / metabolism
  • Nuclear Proteins / metabolism
  • Phosphorylation
  • Promyelocytic Leukemia Protein
  • Protein Binding
  • Protein Kinases / physiology
  • Protein Processing, Post-Translational*
  • Protein Structure, Tertiary
  • Stress, Physiological / metabolism
  • Transcription Factors / metabolism
  • Tumor Suppressor Protein p53 / metabolism*
  • Tumor Suppressor Protein p53 / physiology
  • Tumor Suppressor Protein p53 / radiation effects
  • Tumor Suppressor Proteins
  • Ubiquitin / metabolism
  • Ultraviolet Rays

Substances

  • Anticarcinogenic Agents
  • Carcinogens
  • Neoplasm Proteins
  • Nuclear Proteins
  • Promyelocytic Leukemia Protein
  • Transcription Factors
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • Ubiquitin
  • PML protein, human
  • DNA
  • Acetyltransferases
  • Protein Kinases