Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Oct;4(10):806-13.
doi: 10.1038/nrc1456.

High Interstitial Fluid Pressure - An Obstacle in Cancer Therapy

Affiliations
Review

High Interstitial Fluid Pressure - An Obstacle in Cancer Therapy

Carl-Henrik Heldin et al. Nat Rev Cancer. .

Abstract

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.

Similar articles

See all similar articles

Cited by 487 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback