Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 4 (10), 814-9

Hallmarks of 'BRCAness' in Sporadic Cancers

Affiliations
Review

Hallmarks of 'BRCAness' in Sporadic Cancers

Nicholas Turner et al. Nat Rev Cancer.

Abstract

Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, and the proteins encoded by these genes have distinct functions in related DNA-repair processes. Emerging evidence indicates that these processes are disrupted by numerous mechanisms in sporadic cancers. Collectively, there are properties that define 'BRCAness' - that is, traits that some sporadic cancers share with those occurring in either BRCA1- or BRCA2-mutation carriers. These common properties might have important implications for the clinical management of these cancers.

Similar articles

See all similar articles

Cited by 515 PubMed Central articles

See all "Cited by" articles

MeSH terms

Feedback