Computational approaches to unveiling ancient genome duplications

Nat Rev Genet. 2004 Oct;5(10):752-63. doi: 10.1038/nrg1449.


Recent analyses of complete genome sequences have revealed that many genomes have been duplicated in their evolutionary past. Such events have been associated with important biological transitions, major leaps in evolution and adaptive radiations of species. Here, we consider recently developed computational methods to detect such ancient large-scale gene duplication events. Several new approaches have been used to show that large-scale gene duplications are more common than previously thought.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Computational Biology / methods*
  • Evolution, Molecular*
  • Gene Duplication*
  • Genome*
  • Multigene Family / genetics
  • Phylogeny
  • Species Specificity