Modulatory potential of Spirulina fusiformis on testicular phosphatases in Swiss albino mice against mercury intoxication

Indian J Exp Biol. 2004 Oct;42(10):998-1002.


Administration of mercuric chloride (HgCl2; 5.0 mg/kg body weight) to male Swiss albino-mice resulted in significantly higher levels of testicular acid phosphatase (ACP) and alkaline phosphatase (ALP) activities as compared to control. In combination group where S. fusiformis (800 mg/kg body weight) was given before and after HgCl2 treatment, the mercury induced toxicity reduced in terms of decreased levels of ACP and ALP activities in the testis. The animal treated with only Spirulina did not show any alteration in ACP and ALP values. It is suggested that oral administration of Spirulina can modulate mercury induced testicular toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Phosphatase / metabolism
  • Alkaline Phosphatase / metabolism
  • Animals
  • Bacterial Proteins / pharmacology*
  • Male
  • Mercuric Chloride / toxicity*
  • Mice
  • Spirulina
  • Testis / drug effects*
  • Testis / enzymology*


  • Bacterial Proteins
  • Mercuric Chloride
  • Alkaline Phosphatase
  • Acid Phosphatase