Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Sep:5 Suppl 1:90-3. doi: 10.1080/17434470410019906.


The ALSFRS-R is an attractive primary outcome measure in clinical trials of ALS because it is validated, easy to administer, minimizes dropout, reduces cost, and correlates with survival. Unlike the other standard outcome measures currently employed, the ALSFRS-R is also a measure of global function.

Publication types

  • Review

MeSH terms

  • Activities of Daily Living*
  • Amyotrophic Lateral Sclerosis / drug therapy
  • Amyotrophic Lateral Sclerosis / psychology*
  • Clinical Trials as Topic
  • Humans
  • Outcome Assessment, Health Care / methods*
  • Reproducibility of Results
  • Severity of Illness Index
  • Sickness Impact Profile*