A novel solution for the time-dependent probability of gene fixation or loss under natural selection

Genetics. 2004 Oct;168(2):1081-4. doi: 10.1534/genetics.104.027797.


Kimura proposed a solution for the time-dependent probability of fixation, or loss, of a gene under selection. Example calculations suggest the formulas are prone to numerical inaccuracies. An alternative solution is proposed; the correctness of the solution is confirmed by numerically solving the Kolmogorov backward equation and by simulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biological Evolution
  • Computer Simulation
  • Gene Frequency / genetics*
  • Genes / genetics*
  • Humans
  • Mutation / genetics*
  • Probability
  • Selection, Genetic*
  • Time Factors