Histochemical study of mast cells from the thymus of mice receiving ACTH1-24

Bull Exp Biol Med. 2004 Jul;138(1):93-6. doi: 10.1023/b:bebm.0000046949.29614.09.

Abstract

Synthetic ACTH1-24 analogue administered in a daily dose of 0.01 mg/kg decreased the number and size of mast cells and increased intracellular serotonin concentration. ACTH1-24 induced degranulation of young mast cells and release of undersulfated heparin. Correlation analysis showed that hormonal imbalance produced by ACTH1-24 was accompanied by redistribution of bioamines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Degranulation / drug effects
  • Cosyntropin / administration & dosage
  • Cosyntropin / pharmacology*
  • Heparin / analysis
  • Heparin / metabolism
  • Histocytochemistry
  • Male
  • Mast Cells / drug effects
  • Mast Cells / metabolism*
  • Mast Cells / physiology
  • Mice
  • Mice, Inbred Strains
  • Serotonin / metabolism
  • Thymus Gland / cytology
  • Thymus Gland / drug effects
  • Thymus Gland / metabolism*
  • Time Factors

Substances

  • Cosyntropin
  • Serotonin
  • Heparin