Abstract
Synthetic ACTH1-24 analogue administered in a daily dose of 0.01 mg/kg decreased the number and size of mast cells and increased intracellular serotonin concentration. ACTH1-24 induced degranulation of young mast cells and release of undersulfated heparin. Correlation analysis showed that hormonal imbalance produced by ACTH1-24 was accompanied by redistribution of bioamines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Degranulation / drug effects
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Cosyntropin / administration & dosage
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Cosyntropin / pharmacology*
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Heparin / analysis
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Heparin / metabolism
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Histocytochemistry
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Male
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Mast Cells / drug effects
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Mast Cells / metabolism*
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Mast Cells / physiology
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Mice
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Mice, Inbred Strains
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Serotonin / metabolism
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Thymus Gland / cytology
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Thymus Gland / drug effects
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Thymus Gland / metabolism*
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Time Factors
Substances
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Cosyntropin
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Serotonin
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Heparin