Regression methods for cost-effectiveness analysis with censored data

Stat Med. 2005 Jan 15;24(1):131-45. doi: 10.1002/sim.1794.


A system of seemingly unrelated regression equations is proposed for prognostic factor adjustment and subgroup analysis when comparing two groups in a cost-effectiveness analysis with censored data. Because of the induced dependent censoring on costs and quality-adjusted survival, inverse probability weighting is employed for parameter estimation. The method is illustrated with data from two recent examples using both survival time and quality-adjusted survival time as the measures of effectiveness.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amiodarone / economics
  • Anti-Arrhythmia Agents / economics
  • Canada
  • Cost-Benefit Analysis / methods*
  • Defibrillators, Implantable / economics
  • Female
  • Heart Arrest / prevention & control
  • Humans
  • Hysterectomy, Vaginal / economics
  • Laparoscopy / economics
  • Male
  • Models, Statistical*
  • Quality-Adjusted Life Years
  • Randomized Controlled Trials as Topic / economics*
  • Survival Analysis


  • Anti-Arrhythmia Agents
  • Amiodarone