Analgesic effects of 5-HT3 receptor antagonists

Scand J Rheumatol Suppl. 2004;119:19-23.


Current research suggests an involvement of 5-HT3 receptors in peripheral and central perception and processing of pain as well as in inflammation. Tropisetron and other selective 5-HT3 receptor antagonists have been used successfully for pain reduction and treatment of related symptoms in patients diagnosed with fibromyalgia. This article proposes a concept of the underlying pathophysiology and mechanisms of action of 5-HT3 receptor antagonists in the context of the relevant clinical data on their application in patients with rheumatic disease.

Publication types

  • Review

MeSH terms

  • Analgesia*
  • Humans
  • Pain / drug therapy
  • Pain / physiopathology
  • Receptors, Serotonin, 5-HT3 / physiology
  • Serotonin 5-HT3 Receptor Antagonists*
  • Serotonin Antagonists / therapeutic use*


  • Receptors, Serotonin, 5-HT3
  • Serotonin 5-HT3 Receptor Antagonists
  • Serotonin Antagonists