Familial Barrett's esophagus associated with adenocarcinoma

Gastroenterology. 1992 Apr;102(4 Pt 1):1400-2.


A family with six cases of Barrett's esophagus over three generations is described. The Barrett's esophagus affected only males, and there were three associated adenocarcinomas. The mechanism of inheritance is compatible with an autosomal dominant pattern with nearly complete penetrance. Other case reports in the literature are compared with this familial case of Barrett's esophagus with associated adenocarcinomas.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / etiology
  • Adenocarcinoma / genetics*
  • Adult
  • Aged
  • Barrett Esophagus / etiology
  • Barrett Esophagus / genetics*
  • Esophageal Neoplasms / etiology
  • Esophageal Neoplasms / genetics*
  • Female
  • Humans
  • Male
  • Middle Aged