Urinary fluorine-18 fluorodeoxyglucose excretion with and without intravenous application of furosemide

Acta Med Austriaca. 2004 Aug;31(3):76-8.


Methods: Twenty patients suffering from malignancy received furosemide, twenty patients were examined by FDG-PET without diuretics. Urine volume and radioactivity were measured before and after acquisition. Bladder activity was evaluated qualitatively and quantitatively.

Results: Radioactivity in the bladder was lower and the image quality higher in the furosemide group. SUV values showed a median of 3.0 in the furosemide and 6.0 in the control group. With furosemide, a larger excreted volume was seen compared to the control group. The furosemide group showed a significantly higher ratio of excreted/ injected radioactivity early after injection. However, the totally excreted radioactivity was not significantly different (p = 0.93).

Conclusion: Diuretics cause a higher urine volume with a diluted FDG concentration leading to an improved image quality. Furosemide accelerates early renal FDG elimination, reducing radiation exposure.

MeSH terms

  • Diuretics / urine
  • Female
  • Fluorodeoxyglucose F18 / urine*
  • Furosemide / administration & dosage
  • Furosemide / pharmacology*
  • Humans
  • Image Processing, Computer-Assisted
  • Injections, Intravenous
  • Male
  • Melanoma / diagnostic imaging*
  • Melanoma / urine
  • Middle Aged
  • Positron-Emission Tomography
  • Radiopharmaceuticals / urine


  • Diuretics
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Furosemide