The many faces of filamin: a versatile molecular scaffold for cell motility and signalling

Nat Cell Biol. 2004 Nov;6(11):1034-8. doi: 10.1038/ncb1104-1034.


Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that cross-link cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.

Publication types

  • Review

MeSH terms

  • Brain / abnormalities
  • Cell Movement*
  • Contractile Proteins / genetics
  • Contractile Proteins / metabolism
  • Contractile Proteins / physiology*
  • Female
  • Filamins
  • Humans
  • Male
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism
  • Microfilament Proteins / physiology*
  • Mutation, Missense
  • Signal Transduction*


  • Contractile Proteins
  • Filamins
  • Microfilament Proteins