The article describes two women who had headaches that mimicked chronic paroxysmal hemicrania (CPH). The first patient had a collagen vascular disorder; and the second one, a large malignant tumor in the right frontal lobe. The similarity of the headaches of the first patient to CPH included an absolute response to indomethacin. The existence of these cases may lead to a better understanding of the pathophysiology of CPH. At the same time, their existence also calls for caution in the diagnosis of CPH.