Construction and evaluation of an average CT brain image for inter-subject registration

Cynthia Jongen; Josien P W Pluim; Paul J Nederkoorn; Max A Viergever; Wiro J Niessen

doi:10.1016/j.compbiomed.2003.10.003

Construction and evaluation of an average CT brain image for inter-subject registration

Comput Biol Med. 2004 Dec;34(8):647-62. doi: 10.1016/j.compbiomed.2003.10.003.

Authors

Cynthia Jongen¹, Josien P W Pluim, Paul J Nederkoorn, Max A Viergever, Wiro J Niessen

Affiliation

¹ Image Sciences Institute, University Medical Center Utrecht, Room E01.335, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. cynthia@isi.uu.nl

PMID: 15518650
DOI: 10.1016/j.compbiomed.2003.10.003

Abstract

An average CT brain image is constructed to serve as reference frame for inter-subject registration. A set of 96 clinical CT images is used. Registration includes translation, rotation, and anisotropic scaling. A temporary average based on a subset of 32 images is constructed. This image is used as reference for the iterative construction of the average CT image. This approach is computationally efficient and results in a consistent registration of the 96 images. Registration of new images to the average CT is more consistent than registration to a single CT image. The use of the average CT image is illustrated.

MeSH terms

Brain / diagnostic imaging*
Humans
Stroke / diagnostic imaging*
Tomography, X-Ray Computed / methods*