Postoperative Corynebacterium macginleyi endophthalmitis

J Cataract Refract Surg. 2004 Nov;30(11):2441-4. doi: 10.1016/j.jcrs.2004.04.056.

Abstract

A 72-year-old man with chronic endophthalmitis who received steroid treatment for 3 months came to our center. Sterile endophthalmitis after cataract extraction had been diagnosed. Aqueous samples including smears, classic cultures, and polymerase chain reaction were taken for microbiological study. Amplified DNA was sequenced to identify the pathogen. Polymerase chain reaction amplification was positive for bacteria. Sequence analysis showed Corynebacterium macginleyi as the causal agent in 48 hours. The culture and smear stains from the ocular samples were negative. The patient was successfully treated with vancomycin. Polymerase chain reaction and subsequent DNA-typing were useful in detecting the microorganisms that caused the chronic endophthalmitis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aqueous Humor / microbiology
  • Bacterial Typing Techniques
  • Cataract Extraction
  • Chronic Disease
  • Corynebacterium / genetics
  • Corynebacterium / isolation & purification*
  • Corynebacterium Infections / diagnosis
  • Corynebacterium Infections / drug therapy
  • Corynebacterium Infections / microbiology*
  • Drug Therapy, Combination / therapeutic use
  • Endophthalmitis / diagnosis
  • Endophthalmitis / drug therapy
  • Endophthalmitis / microbiology*
  • Eye Infections, Bacterial / diagnosis
  • Eye Infections, Bacterial / drug therapy
  • Eye Infections, Bacterial / microbiology*
  • Gene Amplification
  • Humans
  • Lens Implantation, Intraocular
  • Male
  • Ofloxacin / therapeutic use
  • Polymerase Chain Reaction
  • Postoperative Complications*
  • Tobramycin / therapeutic use
  • Vancomycin / therapeutic use
  • Vitreous Body / microbiology

Substances

  • Vancomycin
  • Ofloxacin
  • Tobramycin