Outpatient parenteral antibiotic therapy (OPAT) in different countries: a comparison

Int J Antimicrob Agents. 2004 Nov;24(5):473-8. doi: 10.1016/j.ijantimicag.2004.06.004.


In order to assess how outpatient parenteral antibiotic therapy (OPAT) is managed in different countries, we analyzed the data collected in the USA, UK and Italy by the International OPAT Registry using an ad hoc Access/Excel Microsoft program. The analysis of data concerned 9826 patients in the USA, 981 in the UK and 620 in Italy. Differences were observed in several aspects of OPAT management such as the infections treated and the antibiotics utilized. The duration of therapy also differed: it was much longer in Italy (56.0 average days), than in the USA (22.5 days) and UK (19.9 days). Delivery model, delivery route and infusion devices show substantial differences. The present analysis shows that OPAT is carried out with substantial differences in different countries probably according to different programmes and guidelines adopted.

Publication types

  • Comparative Study

MeSH terms

  • Ambulatory Care / statistics & numerical data*
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / adverse effects
  • Humans
  • Infusions, Parenteral / methods*
  • Infusions, Parenteral / standards
  • Outpatients


  • Anti-Bacterial Agents