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Clinical Trial
. 2004 Nov;24(5):491-5.
doi: 10.1016/j.ijantimicag.2004.06.006.

Taurolidine Is Effective in the Treatment of Central Venous Catheter-Related Bloodstream Infections in Cancer Patients

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Clinical Trial

Taurolidine Is Effective in the Treatment of Central Venous Catheter-Related Bloodstream Infections in Cancer Patients

M Koldehoff et al. Int J Antimicrob Agents. .

Abstract

Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis and was shown to be effective in the prevention of catheter-related bloodstream infections (CR-BSI). In this pilot study, we used taurolidine solution as an intravenous (i.v.) lock into the totally implantable intravascular devices of 11 consecutive oncological patients with catheter-related bloodstream infections not responding to systemic antimicrobial chemotherapy. All patients recovered completely from the infection. No adverse drug effects were seen. Three patients were successfully retreated for a recurrent infection. Our data suggest a beneficial role of taurolidine i.v. lock for the therapy of catheter-related bloodstream infections in oncological patients. Taurolidine i.v. lock application is feasible and could especially be useful in infections resistant to antibiotic chemotherapy.

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