Magic touch: how does cell-cell adhesion trigger actin assembly?

Trends Cell Biol. 2004 Nov;14(11):589-93. doi: 10.1016/j.tcb.2004.09.009.

Abstract

The formation of cadherin-mediated cell-cell junctions is accompanied by a profound remodeling of the actin cytoskeleton. The Arp2/3 complex and its activator cortactin drive the assembly of branching actin-filament arrays, and formin-1 promotes the nucleation of non-branching actin filaments. Recruitment of these actin nucleators to nascent adhesions, formation of the links between them and the cytoplasmic cadherin domain, and triggering of their actin-polymerizing functions are vital steps in the development of cell-cell junctions. In this article, I discuss recent results showing that proteins involved in the regulation of actin polymerization have crucial roles in the development and maintenance of the cadherin junctions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Actins / metabolism*
  • Animals
  • Cadherins / genetics
  • Cadherins / metabolism*
  • Cell Adhesion / physiology*
  • Humans
  • Intercellular Junctions / chemistry
  • Intercellular Junctions / metabolism

Substances

  • Actins
  • Cadherins