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Review
. 2004 Dec;143(7):803-18.
doi: 10.1038/sj.bjp.0706012. Epub 2004 Nov 1.

Kinin B1 Receptors: Key G-protein-coupled Receptors and Their Role in Inflammatory and Painful Processes

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Free PMC article
Review

Kinin B1 Receptors: Key G-protein-coupled Receptors and Their Role in Inflammatory and Painful Processes

João B Calixto et al. Br J Pharmacol. .
Free PMC article

Abstract

Kinins are a family of peptides implicated in several pathophysiological events. Most of their effects are likely mediated by the activation of two G-protein-coupled receptors: B(1) and B(2). Whereas B(2) receptors are constitutive entities, B(1) receptors behave as key inducible molecules that may be upregulated under some special circumstances. In this context, several recent reports have investigated the importance of B(1) receptor activation in certain disease models. Furthermore, research on B(1) receptors in the last years has been mainly focused in determining the mechanisms and pathways involved in the process of induction. This was essentially favoured by the advances obtained in molecular biology studies, as well as in the design of selective and stable peptide and nonpeptide kinin B(1) receptor antagonists. Likewise, development of kinin B(1) receptor knockout mice greatly helped to extend the evidence about the relevance of B(1) receptors during pathological states. In the present review, we attempted to remark the main advances achieved in the last 5 years about the participation of kinin B(1) receptors in painful and inflammatory disorders. We have also aimed to point out some groups of chronic diseases, such as diabetes, arthritis, cancer or neuropathic pain, in which the strategic development of nonpeptidic oral-available and selective B(1) receptor antagonists could have a potential relevant therapeutic interest.

Figures

Figure 1
Figure 1
Possible mechanisms underlying B1 receptor upregulation. Stressful stimuli (such as infection and inflammation) are able to activate several signalling pathways including MAPKs, PKC and PI3-K, which in turn might modulate transcriptional factors (e.g. NF-κB, AP-1 and CREB), and are supposed to be crucial for the regulation of B1 receptor expression. AP-1, activating protein-1; AKT/PKB, protein kinase B; CREB, c-AMP response element-binding; ERK, extracellular signal-regulated kinase; JNK, c-jun NH2-terminal kinase; MAPK, mitogen-activated protein kinase; MEKK, mitogen-activated protein kinase kinase kinase; MEK, mitogen-activated protein kinase kinase; NF-κB, nuclear factor-κB; PI3-K, phosphatidylinositol-3 kinase; PLC, phospholipase C; PKC, protein kinase C; TLR, Toll-like receptors.

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