The RAF Proteins Take Centre Stage

Nat Rev Mol Cell Biol. 2004 Nov;5(11):875-85. doi: 10.1038/nrm1498.

Abstract

Since their discovery over 20 years ago, the RAF proteins have been intensely studied. For most of that time, the focus of the field has been the C-RAF isoform and its role as an effector of the RAS proteins. However, a report that implicates B-RAF in human cancer has highlighted the importance of all members of this protein kinase family and recent studies have uncovered intriguing new data relating to their complex regulation and biological functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Models, Biological
  • Molecular Sequence Data
  • Neoplasms / metabolism
  • Protein Isoforms
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins B-raf / metabolism
  • Proto-Oncogene Proteins B-raf / physiology*
  • Proto-Oncogene Proteins c-raf / metabolism
  • Proto-Oncogene Proteins c-raf / physiology*
  • Sequence Homology, Amino Acid
  • Signal Transduction

Substances

  • Protein Isoforms
  • Proto-Oncogene Proteins B-raf
  • Proto-Oncogene Proteins c-raf