Targeting Rab GTPases to distinct membrane compartments

Nat Rev Mol Cell Biol. 2004 Nov;5(11):886-96. doi: 10.1038/nrm1500.


Rab GTPases are key to membrane-trafficking events in eukaryotic cells, and human cells contain more than 60 Rab proteins that are localized to distinct compartments. The recent determination of the structure of a monoprenylated Rab GTPase bound to GDP-dissociation inhibitor provides new molecular details that are relevant to models of Rab delivery. The further discovery of an integral membrane protein that can dissociate prenylated Rab proteins from GDP-dissociation inhibitor gives new insights into the mechanisms of Rab localization.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cattle
  • Cell Line
  • Cell Membrane / metabolism*
  • Cytosol / metabolism
  • GTP Phosphohydrolases / metabolism
  • Guanosine Diphosphate / metabolism
  • Humans
  • Models, Biological
  • Models, Molecular
  • Phosphorylation
  • Phylogeny
  • Protein Prenylation
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae / metabolism
  • rab GTP-Binding Proteins / metabolism
  • rab GTP-Binding Proteins / physiology*


  • Guanosine Diphosphate
  • GTP Phosphohydrolases
  • rab GTP-Binding Proteins