Molecular epidemiology of astrovirus infection in Italian children with gastroenteritis

Clin Microbiol Infect. 2004 Nov;10(11):1025-9. doi: 10.1111/j.1469-0691.2004.00995.x.


Abstract A 1-year study involving 157 gastroenteritis samples was conducted to investigate the role of human astrovirus (HAstV) as a cause of gastroenteritis in Italian children aged < 2 years. The overall incidence of HAstV was 3.1%. Most cases occurred between March and May, and four of the five isolates were of the HAstV-1 type, the other being HAstV-3. Analysis of genetic variability showed that the three HAstV-1 isolates collected in 2000 clustered together, but separately from the 1999 isolate. The results indicated that HAstV should be considered as a potential diarrhoeal pathogen in Italian children.

MeSH terms

  • Astroviridae Infections / epidemiology*
  • Astroviridae Infections / virology
  • Cell Line
  • Child, Preschool
  • Female
  • Gastroenteritis / epidemiology*
  • Gastroenteritis / virology
  • Humans
  • Infant
  • Italy / epidemiology
  • Male
  • Mamastrovirus / classification
  • Mamastrovirus / genetics*
  • Mamastrovirus / isolation & purification
  • Molecular Epidemiology*
  • Phylogeny