Association of VEGF genotype with mRNA level in colorectal adenocarcinomas

Biochem Biophys Res Commun. 2004 Dec 3;325(1):144-50. doi: 10.1016/j.bbrc.2004.10.005.


The mRNA expression of vascular endothelial growth factor (VEGF) was evaluated in colorectal adenocarcinomas and adjacent noncancerous colorectal tissues in 18 Japanese patients. The expression was confirmed to be up-regulated in the colorectal adenocarcinomas, when compared with the noncancerous tissues. Twelve genotypes of VEGF: six positions in the promoter region, two in the 5'UTR, and four in the 3'UTR, and their association with the expression of VEGF mRNA were evaluated. While G-1877A, T-1455C, G-1154A, C702T, and G1612A were not detected, C-2578A, T-1498C, G-1190A, C-634G, C-7T, C936T, and C1451T were found at allele frequencies of 4/36, 15/36, 15/36, 20/36, 8/36, 6/36, and 6/36, respectively, suggesting that C-2578A, G-1154A, and G1612A were associated with a decreased risk for colorectal adenocarcinoma. T-1498C (G-1190A) and C-7T were found to be associated with higher levels of VEGF mRNA, and may be a risk factor for the development of liver metastasis and/or prognosis of colorectal adenocarcinoma.

MeSH terms

  • Adenocarcinoma* / genetics
  • Adenocarcinoma* / metabolism
  • Base Sequence
  • Colorectal Neoplasms* / genetics
  • Colorectal Neoplasms* / metabolism
  • DNA Mutational Analysis
  • Female
  • Genotype*
  • Humans
  • Japan
  • Male
  • Molecular Sequence Data
  • RNA, Messenger / metabolism*
  • Up-Regulation
  • Vascular Endothelial Growth Factor A / genetics*
  • Vascular Endothelial Growth Factor A / metabolism*


  • RNA, Messenger
  • Vascular Endothelial Growth Factor A