Systemic lupus erythematosus presenting with neurological disorders

J Neurol. 1992 Feb;239(2):61-4. doi: 10.1007/BF00862972.


Six patients are described who developed a wide variety of neurological manifestations heralding systemic lupus erythematosus (SLE), which included epileptic seizures, stroke, peripheral polyradiculoneuropathy similar to Guillain-Barré syndrome, transverse myelopathy and multifocal disorders with remitting course mimicking multiple sclerosis. The peculiarity of these cases was that the neurological disorders remained the only manifestations of SLE for many years and the nervous system appeared to be the main target even after the development of systemic SLE. In five patients the prognosis was favourable and corticosteroid treatment led to prolonged remission.

MeSH terms

  • Adolescent
  • Adult
  • Autoantibodies / analysis
  • Demyelinating Diseases / diagnosis
  • Demyelinating Diseases / etiology
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / diagnosis*
  • Middle Aged
  • Monoclonal Gammopathy of Undetermined Significance / etiology
  • Myelitis, Transverse / diagnosis
  • Myelitis, Transverse / etiology
  • Nervous System Diseases / diagnosis*
  • Nervous System Diseases / etiology
  • Optic Neuritis / diagnosis
  • Optic Neuritis / etiology
  • Seizures / diagnosis
  • Seizures / etiology


  • Autoantibodies