Ocular manifestations of graft versus host disease

Curr Opin Ophthalmol. 2004 Dec;15(6):503-7. doi: 10.1097/01.icu.0000143684.22362.46.


Purpose of review: A review of the current literature regarding the ocular manifestations and management of graft versus host disease is presented.

Recent findings: A variety of systemic and topical anti-inflammatory or immunomodulatory agents, including prednisolone acetate, cyclosporine A, FK506, autologous serum, and retinoic acid show promise in controlling ocular graft versus host disease.

Summary: Graft versus host disease is a common manifestation of allogeneic stem cell transplantation. Ocular manifestations are found in a majority of patients and may be the presenting symptom. Ocular findings include keratoconjunctivitis sicca, pseudomembranous conjunctivitis, corneal ulceration and perforation, and microvascular retinopathy. Systemic and local therapy may be used to control ocular disease.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Bone Marrow Transplantation / adverse effects
  • Eye Diseases / drug therapy
  • Eye Diseases / etiology*
  • Graft vs Host Disease / complications*
  • Graft vs Host Disease / etiology
  • Humans
  • Immunologic Factors / therapeutic use
  • Transplantation, Homologous / adverse effects


  • Anti-Inflammatory Agents
  • Immunologic Factors