Magnesium orotate in myocardial and neuronal protection

Rom J Intern Med. 1999 Jan-Mar;37(1):91-7.


The nervous tissue and the myocardium have in common many denominators, such as: the inability to renew to substitute the severely damaged or dead cells, the role of the membrane electric activity, the presence of similar systems for antioxidation protection, which are obviously involved in pathologic events a.s.o. Aggressive factors mainly act by free radicals injury and increase in cytosolic calcium level. Magnesium orotate molecule includes two synergic protective components: orotic acid and magnesium. Moreover, the orotic acid behaves as a transporter, carrying magnesium into the cells. The antioxidation protective effect of the orotic acid is mainly due to the pirimidinic bases that favor and increased synthesis of enzymes which act as free radical scavengers. The cell antioxidation protective system is dramatically impaired following heavy aggressions such as the ischemia-reperfusion process. Magnesium orotate improves the survival of cells situated within the perinecrotic areas as well as of the cells secondarily damaged during the so-called "second wind".

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Heart / drug effects*
  • Humans
  • Myocardium / pathology
  • Neurons / drug effects*
  • Orotic Acid / analogs & derivatives*
  • Orotic Acid / pharmacology*
  • Protective Agents / pharmacology*


  • Antioxidants
  • Protective Agents
  • Orotic Acid
  • magnesium orotate