Complications of the nephrotic syndrome and their treatment

Clin Nephrol. 2004 Oct;62(4):245-59. doi: 10.5414/cnp62245.


The nephrotic syndrome occurs in association with a diverse array of primary and secondary glomerular disorders. Despite the different etiologies, many of the clinical effects are similar. This review focuses on the pathogenesis and treatment of edema formation, hyperlipidemia, and the hypercoagulable state. Major abnormalities of the endocrine system and evidence of erythropoietin deficiency will be reviewed. Finally, non-specific treatments aimed at reducing proteinuria will also be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Edema / etiology
  • Edema / therapy*
  • Endocrine System Diseases / etiology
  • Endocrine System Diseases / therapy*
  • Humans
  • Hyperlipidemias / etiology
  • Hyperlipidemias / therapy*
  • Nephrotic Syndrome / complications*
  • Proteinuria / etiology
  • Proteinuria / therapy*
  • Thrombophilia / etiology
  • Thrombophilia / therapy*