Scaling of F-actin network rheology to probe single filament elasticity and dynamics

Phys Rev Lett. 2004 Oct 29;93(18):188102. doi: 10.1103/PhysRevLett.93.188102. Epub 2004 Oct 29.


The linear and nonlinear viscoelastic response of networks of cross-linked and bundled cytoskeletal filaments demonstrates remarkable scaling with both frequency and applied prestress, which helps elucidate the origins of the viscoelasticity. The frequency dependence of the shear modulus reflects the underlying single-filament relaxation dynamics for 0.1-10 rad/sec. Moreover, the nonlinear strain stiffening of such networks exhibits a universal form as a function of prestress; this is quantitatively explained by the full force-extension relation of single semiflexible filaments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Actins / chemistry*
  • Actins / metabolism
  • Actins / physiology
  • Cross-Linking Reagents / chemistry
  • Cytoskeleton / chemistry*
  • Cytoskeleton / metabolism
  • Elasticity
  • Rheology / methods
  • Thermodynamics
  • Viscosity


  • Actins
  • Cross-Linking Reagents
  • scruin protein, Horseshoe Crab