Bub1, a gatekeeper for Cdc20-dependent mitotic exit

Dev Cell. 2004 Nov;7(5):634-5. doi: 10.1016/j.devcel.2004.10.012.


The mitotic spindle assembly checkpoint arrests cells at metaphase by suppressing Cdc20, a protein required to trigger ubiquitination and consequent degradation of cyclin B. New evidence from Tang et al. appearing in the November 5th issue of Molecular Cell finds that one of the checkpoint proteins, Bub1, specifically phosphorylates Cdc20 to suppress APC/C activation.

MeSH terms

  • Adenomatous Polyposis Coli Protein / physiology
  • Animals
  • Cdc20 Proteins
  • Cell Cycle Proteins / physiology*
  • Humans
  • Mitosis*
  • Protein Kinases / physiology*
  • Protein-Serine-Threonine Kinases


  • Adenomatous Polyposis Coli Protein
  • Cdc20 Proteins
  • Cell Cycle Proteins
  • CDC20 protein, human
  • Protein Kinases
  • BUB1 protein, human
  • Bub1 spindle checkpoint protein
  • Protein-Serine-Threonine Kinases