Stuck in Division or Passing Through: What Happens When Cells Cannot Satisfy the Spindle Assembly Checkpoint

Dev Cell. 2004 Nov;7(5):637-51. doi: 10.1016/j.devcel.2004.09.002.

Abstract

Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-mitosis), a fact that has useful clinical ramifications. However, this delay is seldom permanent, and in the presence of an active SAC most cells ultimately escape mitosis and enter the next G1 as tetraploid cells. This review defines and discusses the various factors that determine how long a cell remains in mitosis when it cannot satisfy the SAC and also discusses the cell's subsequent fate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cellular Senescence
  • G1 Phase
  • Humans
  • Kinetochores / physiology
  • Microtubules / physiology
  • Mitosis / physiology*
  • Models, Biological
  • Necrosis
  • Nocodazole / toxicity
  • Spindle Apparatus / drug effects
  • Spindle Apparatus / physiology*
  • Time Factors

Substances

  • Nocodazole