Matrix metalloproteinases and the gut - new roles for old enzymes

Curr Opin Pharmacol. 2004 Dec;4(6):546-50. doi: 10.1016/j.coph.2004.06.005.


Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. To date, more than 24 different human MMPs have been identified. MMP activity is important in diseases such as arthritis, atherosclerosis, periodontal diseases and cancer. Recent data suggest that MMPs are involved in tissue injury and healing in the human gut.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Extracellular Matrix / drug effects
  • Extracellular Matrix / metabolism*
  • Gastrointestinal Diseases / enzymology*
  • Gastrointestinal Tract / enzymology
  • Humans
  • Matrix Metalloproteinases / metabolism*
  • Matrix Metalloproteinases / pharmacology
  • United Kingdom


  • Matrix Metalloproteinases