Matrix metalloproteinases and the gut - new roles for old enzymes

Sylvia L F Pender; Thomas T MacDonald

doi:10.1016/j.coph.2004.06.005

Matrix metalloproteinases and the gut - new roles for old enzymes

Curr Opin Pharmacol. 2004 Dec;4(6):546-50. doi: 10.1016/j.coph.2004.06.005.

Authors

Sylvia L F Pender¹, Thomas T MacDonald

Affiliation

¹ Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK.

PMID: 15525541
DOI: 10.1016/j.coph.2004.06.005

Abstract

Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. To date, more than 24 different human MMPs have been identified. MMP activity is important in diseases such as arthritis, atherosclerosis, periodontal diseases and cancer. Recent data suggest that MMPs are involved in tissue injury and healing in the human gut.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Extracellular Matrix / drug effects
Extracellular Matrix / metabolism*
Gastrointestinal Diseases / enzymology*
Gastrointestinal Tract / enzymology
Humans
Matrix Metalloproteinases / metabolism*
Matrix Metalloproteinases / pharmacology
United Kingdom

Substances

Matrix Metalloproteinases