Nestin expression--a property of multi-lineage progenitor cells?

Cell Mol Life Sci. 2004 Oct;61(19-20):2510-22. doi: 10.1007/s00018-004-4144-6.


Tissue-specific progenitor cells are characterized by proliferation and differentiation, but, in contrast to embryonic stem (ES) cells, have limited capacities for self-renewal and no tumourigenic potential. These latter traits make progenitor cells an ideal source for regenerative cell therapies. In this review, we describe what is currently known about nestin, an intermediate filament first identified in neuroepithelial stem cells. During embryogenesis, nestin is expressed in migrating and proliferating cells, whereas in adult tissues, nestin is mainly restricted to areas of regeneration. We show that nestin is abundant in ES-derived progenitor cells that have the potential to develop into neuroectodermal, endodermal and mesodermal lineages. Although it remains unclear what factors regulate in vitro and in vivo expression of nestin, we conclude that nestin represents a characteristic marker of multi-lineage progenitor cells and suggest that its presence in cells may indicate multi-potentiality and regenerative potential.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Embryo, Mammalian / cytology
  • Exons
  • Humans
  • Immunohistochemistry
  • Intermediate Filament Proteins / biosynthesis*
  • Intermediate Filament Proteins / metabolism
  • Liver / metabolism
  • Mice
  • Models, Biological
  • Nerve Tissue Proteins / biosynthesis*
  • Nerve Tissue Proteins / metabolism
  • Nestin
  • Pancreas / metabolism
  • Rats
  • Stem Cells / cytology
  • Stem Cells / metabolism*


  • Intermediate Filament Proteins
  • NES protein, human
  • Nerve Tissue Proteins
  • Nes protein, mouse
  • Nes protein, rat
  • Nestin