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, 6 (6), 429-35

Helicobacter Pylori Infection and Gastric Cancer: Host, Bug, Environment, or All Three?


Helicobacter Pylori Infection and Gastric Cancer: Host, Bug, Environment, or All Three?

Rena J Menaker et al. Curr Gastroenterol Rep.


Helicobacter pylori is a common bacterial pathogen that colonizes the gastric mucosa of over 50% of the world's population. All infected individuals exhibit chronic gastric inflammation, and approximately 1% of patients develop gastric cancers, including adenocarcinomas and mucosal-associated lymphoid tissue lymphomas. In 1994, the World Health Organization International Agency for Research on Cancer classified H. pylori as a type I, or definite carcinogen. Because the prevalence of gastric cancers among H. pylori-infected patients varies between individuals, countries, and geographic areas, H. pylori disease-related outcomes are believed to be determined by an interplay between host factors, bacterial factors, and their interaction with the environment. This review highlights recent advances in our knowledge on H. pylori disease pathogenesis, focusing on the role of the host, bacteria, and environment in the development of gastric carcinoma.

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Cited by 5 PubMed Central articles


    1. Cancer Res. 1994 Jul 15;54(14):3845-52 - PubMed
    1. Helicobacter. 2003 Jun;8(3):235-43 - PubMed
    1. Scand J Gastroenterol. 2001 Mar;36(3):247-50 - PubMed
    1. J Infect Dis. 2003 Jul 15;188(2):272-81 - PubMed
    1. Oncogene. 1996 Aug 15;13(4):853-6 - PubMed

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