An LEA group 3 family member is involved in survival of C. elegans during exposure to stress

FEBS Lett. 2004 Nov 5;577(1-2):21-6. doi: 10.1016/j.febslet.2004.09.049.


In order to establish a functional role for late embryogenesis abundant (LEA) proteins in response to stress conditions in Caenorhabditis elegans, we silenced the expression of an LEA (Ce-lea-1) gene and determined the survival of worms under stress conditions. Ce-lea-1 transcription was induced during dehydration of C. elegans dauer juveniles. Following partial silencing of Ce-lea-1 transcription, we demonstrated a specific and significant reduction in worm survival during induction of desiccation, osmotic and heat stress. Together, these results establish a functional role for Ce-lea-1 in stress survival of C. elegans and suggest that Ce-lea-1 may function as a component that is common to the responses to the examined stress conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / physiology*
  • DNA Primers
  • Dehydration / physiopathology*
  • Gene Silencing
  • Heat Stress Disorders
  • Osmotic Pressure
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription, Genetic


  • Caenorhabditis elegans Proteins
  • DNA Primers