Signaling kinases modulated by 4-hydroxynonenal

Free Radic Biol Med. 2004 Dec 1;37(11):1694-702. doi: 10.1016/j.freeradbiomed.2004.08.027.


The interaction of 4-hydroxynonenal (HNE) with a variety of kinases variously involved in cell signaling is now a matter of active investigation. In particular, findings with regard to the effect of HNE on different components of the protein kinase C family and the mitogen-activated protein kinase complex already provide reliable indications of a potential role of this aldehyde as a cell signal messenger. Such a role appears further supported by the clear-cut evidence of up-regulation of receptor tyrosine kinases and down-regulation of the nuclear factor kappa B system, produced by HNE concentrations actually detectable in pathophysiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aldehydes / chemistry
  • Aldehydes / pharmacology*
  • Animals
  • Down-Regulation
  • Humans
  • I-kappa B Kinase
  • Protein-Serine-Threonine Kinases / drug effects*
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Serine-Threonine Kinases / physiology
  • Receptor Protein-Tyrosine Kinases / drug effects*
  • Receptor Protein-Tyrosine Kinases / physiology
  • Signal Transduction / drug effects*
  • Up-Regulation


  • Aldehydes
  • Receptor Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human
  • 4-hydroxy-2-nonenal