Protein kinase C increase in rat brain cortical membranes may be promoted by cognition enhancing drugs

Life Sci. 1992;50(16):PL125-8. doi: 10.1016/0024-3205(92)90465-2.

Abstract

Protein Kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain cortices after in vivo treatment with two cognition enhancers: oxiracetam and alpha-glicerylphosphorylcholine. Both drugs induced an increase (+40-50%) of PKC particulate activity at 1 hr after the treatment. The effect was transient; at 5 hours PKC activity was lower than in controls. The dose response curve to oxiracetam was bell shaped, the increase of PKC being significant at 100 mg/kg. At higher doses the drug induced a decrease in enzyme activity. The increased PKC activity may be related to the cortical effects of these compounds.

MeSH terms

  • Animals
  • Cerebral Cortex / enzymology*
  • Cognition / drug effects
  • Desipramine / pharmacology
  • Glycerylphosphorylcholine / pharmacology*
  • Male
  • Protein Kinase C / metabolism*
  • Pyrrolidines / pharmacology*
  • Rats
  • Rats, Inbred Strains

Substances

  • Pyrrolidines
  • Glycerylphosphorylcholine
  • Protein Kinase C
  • oxiracetam
  • Desipramine