Demographic factors that influence the neutralizing antibody response in recipients of recombinant HIV-1 gp120 vaccines

J Infect Dis. 2004 Dec 1;190(11):1962-9. doi: 10.1086/425518. Epub 2004 Oct 28.

Abstract

We compared neutralizing antibody responses in human immunodeficiency virus (HIV) type 1 gp120 vaccine recipients by age, sex, and race. Four phase 1 or 2 trials involving 505 vaccinated subjects were analyzed. Age and sex had no detectable effect on neutralizing antibody responses. However, race influenced the response to one vaccine, MN gp120, in alum. Four inoculations with this vaccine generated higher serum titers of neutralizing antibodies in African Americans than in whites. Despite potent neutralization of T cell line-adapted HIV-1, serum from these African Americans failed to neutralize primary HIV-1 isolates. Neutralizing antibody responses did not differ between races when SF2 gp120 in MF-59 was administered either alone or with recombinant canarypox vCP205; they also did not differ when vCP1452 was administered either alone or with AIDSVAX B/B in alum. These data indicate that race may affect the neutralizing antibody response to some gp120 immunogens. To fully evaluate immunogenicity, clinical trials of candidate vaccines should enroll diverse populations of subjects.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Vaccines / administration & dosage
  • AIDS Vaccines / immunology*
  • African Americans
  • Age Factors
  • Clinical Trials as Topic
  • Demography*
  • European Continental Ancestry Group
  • Female
  • HIV Antibodies / biosynthesis*
  • HIV Envelope Protein gp120 / administration & dosage
  • HIV Envelope Protein gp120 / immunology*
  • HIV Infections / ethnology
  • HIV Infections / immunology
  • HIV Infections / prevention & control
  • HIV-1 / immunology*
  • Humans
  • Male
  • Neutralization Tests
  • Retrospective Studies
  • Sex Factors
  • Vaccination
  • Vaccines, Synthetic / immunology

Substances

  • AIDS Vaccines
  • HIV Antibodies
  • HIV Envelope Protein gp120
  • Vaccines, Synthetic