Kinetochores: if you build it, they will come

Curr Biol. 2004 Nov 9;14(21):R921-3. doi: 10.1016/j.cub.2004.10.014.


Successful mitosis depends critically on the segregation of chromosomes by kinetochore microtubules. A recent paper describes a conserved protein network from Caenorhabditis elegans that is composed of three classes of molecules, each of which contributes uniquely to the building of the kinetochore-microtubule attachment site.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans
  • Chromosome Segregation / physiology*
  • Kinetochores / metabolism*
  • Microtubule-Associated Proteins / metabolism*
  • Microtubules / metabolism*
  • Models, Chemical


  • Microtubule-Associated Proteins