Diverse mechanisms regulate stem cell self-renewal

Curr Opin Cell Biol. 2004 Dec;16(6):700-7. doi: 10.1016/j.ceb.2004.09.004.


To what extent are the pathways that regulate self-renewal conserved between stem cells at different stages of development and in different tissues? Some pathways play a strikingly conserved role in regulating the self-renewal of diverse stem cells, whereas other pathways are specific to stem cells in certain tissues or at certain stages of development. Recent studies have highlighted differences between the self-renewal of embryonic, fetal and adult stem cells. By understanding these similarities and differences we may come to a molecular understanding of how stem cells replicate themselves and why aspects of this process differ between stem cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Lineage
  • Cell Proliferation
  • Drosophila Proteins / metabolism
  • Embryo, Mammalian / cytology*
  • Hedgehog Proteins
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Membrane Proteins / metabolism
  • Models, Biological
  • Polycomb Repressive Complex 1
  • Receptors, Notch
  • Signal Transduction
  • Stem Cells / cytology*
  • Stem Cells / physiology*
  • Time Factors
  • Wnt Proteins


  • Drosophila Proteins
  • Hedgehog Proteins
  • Intercellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Pc protein, Drosophila
  • Receptors, Notch
  • Wnt Proteins
  • hh protein, Drosophila
  • Polycomb Repressive Complex 1