Centrally active 5-HT receptor agonists and antagonists

Neurosci Biobehav Rev. Spring 1992;16(1):75-82. doi: 10.1016/s0149-7634(05)80054-5.


Eleven subtypes of central 5-HT receptor have so far been postulated, four of which have been cloned (5-HT1A, 5-HT1C, 5-HT1D and 5-HT2) and a fifth (the 5-HT3 receptor) purified. The present review discusses the agonists and antagonists which act at these subtypes with respect to their degree of selectivity and in vivo potency. Selective agonists exist for the 5-HT1A, 5-HT1B and 5-HT3 receptors and selective antagonists for the 5-HT2 and 5-HT3 receptors.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / physiology*
  • Serotonin Antagonists / pharmacology*


  • Receptors, Serotonin
  • Serotonin Antagonists