Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection

Nat Immunol. 2004 Dec;5(12):1227-34. doi: 10.1038/ni1136. Epub 2004 Nov 7.

Abstract

Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound phenotypic and functional changes including the acquisition of enhanced antigen-presenting capacity and the ability to recognize different microbial structures through Toll-like receptor 4. The conversion of pDCs into mDCs is also induced by the injection of double-stranded RNA and requires type I interferons. Our results establish a precursor-product developmental relationship between these two DC subsets and highlight unexpected plasticity of bone marrow pDCs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bone Marrow Cells / cytology*
  • Bone Marrow Cells / virology*
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Dendritic Cells / cytology*
  • Dendritic Cells / drug effects
  • Dendritic Cells / immunology
  • Dendritic Cells / virology*
  • Interferon Type I / deficiency
  • Interferon Type I / genetics
  • Interferon Type I / pharmacology
  • Kinetics
  • Lymphocytic choriomeningitis virus / immunology
  • Lymphocytic choriomeningitis virus / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myeloid Cells / cytology*
  • Myeloid Cells / virology*
  • Phenotype
  • Reproducibility of Results
  • Spleen / cytology
  • Spleen / immunology
  • Virus Diseases / immunology*
  • Virus Diseases / pathology
  • Virus Diseases / virology

Substances

  • Interferon Type I