[The genetics HIV cohort of the Swiss HIV Cohort Study--facing the new challenges in medicine]

Ther Umsch. 2004 Oct;61(10):613-8. doi: 10.1024/0040-5930.61.10.613.
[Article in German]

Abstract

Host genetic factors determine the individual natural course of HIV infection and influence the response to therapy and the occurrence of adverse events to treatment. Variants of multiple genes are associated with faster but also slower development of severe immunodeficiency. However, only very rarely the variant of one single gene explains a specific clinical phenotype. But multiple genetic marker form a complex trait, which is difficult to analyse biostatistically. Research in this rapidly evolving field asks for structures in which hypotheses can be generated and evaluated and which combine basic and diagnostic and therapeutic research. The large amount of prospective information on HIV disease natural history and treatment response of the Swiss HIV Cohort Study will make of the Genetics project an excellent test-setting for some of the immediate difficulties in this research field: validation of new markers and modelling of complex traits.

Publication types

  • Comparative Study
  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use
  • Anti-Retroviral Agents / administration & dosage
  • Anti-Retroviral Agents / adverse effects
  • Anti-Retroviral Agents / therapeutic use
  • Biomedical Research
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Disease Progression
  • Genetic Markers
  • Genetic Research
  • HIV Infections / drug therapy
  • HIV Infections / epidemiology*
  • HIV Infections / genetics*
  • Humans
  • Phenotype
  • Switzerland / epidemiology
  • Time Factors

Substances

  • Anti-HIV Agents
  • Anti-Retroviral Agents
  • Genetic Markers