Mitochondrial disorders in pediatrics. Clinical, biochemical, and genetic implications

Pediatr Clin North Am. 1992 Apr;39(2):319-34. doi: 10.1016/s0031-3955(16)38297-9.


Disorders secondary to mitochondrial dysfunction are likely to be common in the population. The clinical aspects of these disorders are varied and may follow nonclassic inheritance patterns. These disorders serve to illustrate the importance of the clinical history and family history in directing diagnostic approaches.

Publication types

  • Review

MeSH terms

  • Child
  • DNA / genetics
  • DNA, Mitochondrial / genetics
  • Humans
  • Metabolism, Inborn Errors / diagnosis
  • Metabolism, Inborn Errors / drug therapy
  • Metabolism, Inborn Errors / genetics*
  • Metabolism, Inborn Errors / physiopathology
  • Mitochondria / metabolism*
  • Mutation
  • Pedigree


  • DNA, Mitochondrial
  • DNA