"One size fits it all": translocation of foreign antigens by Yersinia type III secretion system (TTSS) leads to concomitant CD4 and CD8 T-cell priming

Int J Med Microbiol. 2004 Oct;294(5):313-7. doi: 10.1016/j.ijmm.2004.03.002.

Abstract

Live replicating bacteria expressing heterologous antigens are vaccine candidates that are able to induce complex immune responses. Yersinia pseudotuberculosis employs a type III secretion system for translocation of several virulence factors directly to the cytosol of eukaryotic cells. Mice orally inoculated with an attenuated recombinant Yersinia strain translocating a chimeric Yersinia outer protein E (YopE) molecule reveal high numbers of foreign antigen-specific CD4 and CD8 T cells. Thus, cytosolic display of a single hybrid protein results in concomitant CD4 and CD8 T-cell priming. This "one-size-fits-it-all"-feature of Yersinia-translocated heterologous antigens might be advantageous to mount T-cellular immune responses against complex microbes and tumors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Antigens, Bacterial / biosynthesis
  • Antigens, Bacterial / immunology
  • Bacterial Outer Membrane Proteins / immunology*
  • Bacterial Vaccines / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Histocompatibility Antigens Class II / immunology
  • Immunization / methods
  • Mice
  • Recombinant Proteins / immunology
  • Vaccines, Attenuated / immunology
  • Yersinia pseudotuberculosis / immunology
  • Yersinia pseudotuberculosis / physiology*

Substances

  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • Histocompatibility Antigens Class II
  • Recombinant Proteins
  • Vaccines, Attenuated
  • yopE protein, Yersinia