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. 2004 Nov;82(5):1348-51.
doi: 10.1016/j.fertnstert.2004.04.047.

Heritability of Menopausal Age in Mothers and Daughters

Affiliations

Heritability of Menopausal Age in Mothers and Daughters

Kristel M van Asselt et al. Fertil Steril. .

Abstract

Objective: To determine the heritability of age at natural menopause from mother-daughter pairs.

Design: Two-generation families were selected to study heritability of menopausal age.

Setting: Subjects were drawn from a population-based study.

Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age.

Intervention(s): None.

Main outcome measure(s): The heritability of age at natural menopause estimated by a random-effects model.

Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated.

Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed.

Comment in

  • Modeling age at menopause.
    Vink J, Boomsma D. Vink J, et al. Fertil Steril. 2005 Apr;83(4):1068. doi: 10.1016/j.fertnstert.2005.01.004. Fertil Steril. 2005. PMID: 15820835 No abstract available.

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