Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance

Curr Opin Investig Drugs. 2004 Oct;5(10):1045-50.


Peroxisome proliferator activated receptors (PPARs) are a group of ligand-activated transcription factors that play critical roles in the regulation of energy metabolism. Synthetic agonists for these receptors are used in the treatment of type 2 diabetes mellitus and dyslipidemia. Current data linking PPAR and/or PPAR ligands with the treatment of insulin resistance will be critically reviewed, with the focus on important advances over the past year.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use*
  • Insulin Resistance*
  • Ligands
  • Peroxisome Proliferator-Activated Receptors / agonists*


  • Hypoglycemic Agents
  • Ligands
  • Peroxisome Proliferator-Activated Receptors